I don't always like the restrictions of using FQ's. Sometimes I want longer strips so that I can get more cuts out of a 1/4 yard's length. Sometimes the FQ's aren't exactly 18 X 22 so I end up short on fabric. They also are more expensive, you can often buy a 1/3 yard cut for the same price as a FQ.
But, I do have a stash of FQ's that work beautifully for some of my projects :D:D:D