I developed carpal tunnel after years of being a secretary and transcriptionist, so all that typing did my wrist in. I hand quilted only one quilt - a full size qult, but after that I could only quilt for small periods of time. I use the wrist brace at night which significantly improves the pain during the day. When I was doing transcription work, I used elastic wristlets that also helped a lot. When the pain gets too bad, I take breaks that helps relieve the pressure and the pain. Just like the arthritis in my back, shoulders, knees and ankles, I take it one day at a time, and some days minutes at a time, but mostly I get through it by pacing myself and what I do.