I have RLS and taking a Parkinson's med for it. For me it is the result of a condition called Pernicious Anemia which means that my body does not absorb vitamin B12 though its normal route. The usual route of absorbsion for B12 is through the intestinal wall. With this condition the cells in the intestinal wall become small enough that the B12 molecules can't pass through and attach to blood cells and you become anemic. I have to inject B12 in order to get it into my bloodstream. Lack of B12 has severe consequences for the nervous system. When I finally went to the Dr and was diagnosed I couldn't move my left leg without moving it with my hands. I thought I might have MS. I was told that if I had waited much longer that it could have affected my heart and resulted in death. B12 injections reversed most of the symptoms I was experiencing but this is a permanent condition. I had mentioned it to two doctors prior to being diagnosed but they dismissed it as psychological. Sitting for long periods of time is virtually impossible and that makes it difficult to take a trip on a plane without sedation. We drive anywhere we want to go so I can get out and walk around or stomp my foot if I need to. My DH is used to it but if I have to sit and wait in a public place people become uncomfortable with all my movement and I am sure they think I am a nut case. At it's least it feels like bugs constantly crawling on my legs and bottom of my left foot. It is sometimes so annoying that I will hit my leg to try and divert the brains focus. Combine it with menopause and you have the perfect storm for a miserable nights sleep and worn out sheets. Ann in Tn