I think it will work. The only problem for me would be -- the quilt would start getting too heavy about half way through.
Also, I pull up my side table on the left side of me to keep the quilt from sliding off of the sewing table, so I don't have to tug on it all the time. I would also do the batting abd backing at the same time. Glue stick baste as you go, and pin where needed. Be sure to show us how it turns out.
Syl