Yes, remember to relax. I have arthritis in my right wrist (among other places) and sometimes wear a carpal tunnel brace. Quilting was not the cause, however, I've broken that wrist 4 times, once defending myself from a crazed druggy with a knife. I figure that my body is entitled to complain once in a while. I have not treated it gently. I have made over 500 quilts. My doc sees no damage from quilting, only from being TENSE while quilting.