If you are traveling by car, have the room and have a machine that is not overly fussy about being moved, I say absolutely take it! Better to have it and decide you don't want to sew than to not have it and want to spend your free time sewing.
Think about where you usually start - piecing the background, a particular embellishment or two - and take those materials, saving the rest or the things that vary a lot for when you get home.
Alternatively, take hand work - a project nearing completion that is at the stage where it embellishments need to be sewn by hand, or needs binding.
Be sure to take a light with you, as many hotel rooms do not have sufficient lighting for any type of sewing.