My suggestion would be to make your own kit before leaving home, with all the fabrics cut, and ready to sew. By doing so, you can probably eliminate taking a cutting mat, and rotary cutter. Remember thread snippers, thread, replacement needles, your machine tools kit ... and anything else you might need.
For sure, take along an extension cord and an extra light source as hotel rooms are notorious for lighting that is not the best for sewing.
Try to pack your machine and all your necessary items into one rolling suitcase, so it's simple to take into the room. If leaving in the room during the day, I'd pack it all back up just so you don't have to worry about anything happening.