I'm right handed, but about 12 years ago, I fell fracturing my right wrist. It was an enormous inconvenience, since I worked as a legal assistant in a law office. Also, trying to write, sign my name, etc. Of course, my wrist did finally mend, and I had not gotten really into quilting at that time. Do be very careful using a rotary cutter left-handed. It's really easy to cut yourself using it right-handed if you're right handed, much less using your non-dominant hand for something it's not accustomed to doing. Take care and heal!