My hometown is right across the river from Lancaster (York) so,I get up to,visit family (and go to quilt shows, of course!!) at least a couple times a year. I've been to almost all of them in the area (more than once) and love them all, but I want to also say I never miss The Quilt & Fabric Shack on Old Philadelphia Pike (Rt. 340) - in Bird In Hand. Amish-owned shops are terrific - they have the same fabrics as quilt shops but the prices are much better.
Just as a note - in case you have a chance to get to Hagerstown, MD there are two shows I never miss. Both are off I81 - Wilson's at X6 (Maugans Ave) has wonderful fabric bundles - I buy them and just pet them!! and Traditions at the White Swan (X9) which is terrific for reproduction fabrics.
Sandy in Mooresville, NC