moonhoney2, if it's the computer that seems to be giving you fits, maybe you could try a different keyboard, like one of those spread out ones? I've found a "wrist rest" works well at keeping my entire hand at the same level, there by less fatique.
The other thing you might try is a different mouse. Perhaps a touch sensitive one? Or perhaps if that is the kind you use you might go to the store and see what kinds they have that "fit" your hand, it used to be only one or two brands "fit" but now they are all doing it and for not much money. Before I started using a laptop all the time, (with the touch sensitive pad) I had a wrist rest for my mouse as well. One of the gel ones that has the attached mouse pad. LOL I had TWO one for work and one for home.