the truth first: i reorganize about 3 times a year. within a few days it looks again as though a bomb went off.
so, for approximately two days, three times a year, my fabs are sorted into see-through plastic drawers by color, darkest on bottom. fat quarters are in a separate drawer when possible, but above or below the yardage in that color group.
holiday, baby prints and kiddie prints are separate but also grouped by color.
once i've selected a collection of fabs for a specific project they go into their own drawer, along with the pattern i plan to use.