I have some nasty ones in my heels. I have used orthotics for about 10 years now. I can finally wear sandals for a short time but cannot walk barefoot on any hard floor. I don't remember what I took for that pain.
I have also had them in my shoulders. I used anti-inflammatory meds such as Aleve and x-strength Tylenol, and when they were bad enough, Vicotin. Surgery took care of them.