I have a couple books that show you how to quilt in sections.
You make a section of the quilt and quilt it...then make another section and quilt that...by the time you have the top done, you have almost finished the whole thing.
I have fibromyalgia and wrestling a whole quilt all at once, for me is unthinkable!
Divide and Conquer
Marti Michell's Quilting In Sections