I think it depends - to a certain extent - on what you plan to make with it.
Is it going to be in a "ladies guest room" and mostly just to "look pretty"?
Or
Is it going to be used by 10 year old boys that think quilts are to be used for tents and capes?
Or
In a glass covered wall hanging?
Washability? Durability? Does it matter?
You said that you've done a lot of sewing of garments - just transfer that knowledge of fabric behavior to quilted items.
(Think facing, interfacing, and fashion fabric) - except the interfacing is now batting and usually somewhat squishy and bulky)