I would start in the middle and work your way out. Make sure is is securely spray basted or pinned. I always baste around the edges before starting. I found if I had puckers that's where they were and stitching helped stabilize it. I still get butterflies in my stomach every time I start quilting a new quilt. One other thing that may help is getting quilting gloves. They help you move the fabric. I have a pair from Fons and Porter, but my favorites were some gardening gloves with rubber dots on them. And they were so much cheaper. Have fun and keep us posted.