I've only thought that males spray. My cats (male or female, past and present) would get "the works" as soon as the vet says is possible. That way the males wouldn't have know about the need to spray. I find it hard to believe a vet would suggest putting down a cat for spraying-adopt it out. Bottom line, I'm at a loss about a female spraying. I'm a sucker for cuteness and I'd have that kitty in my house AFTER flea treatment and a good worming. If it was being seen by a good vet, they should know about the bladder problems and treat accordingly.