Sorry to say I have had your experience. Only one female ever gave us grief..and we tried for 2 years to break the habit...and eventually helped her across rainbow bridge. There was no medical problem and we were not overcrowded and nothing had changed in the house (that we were aware of).Euthanasia is sometimes the greatest gift you can give a pet---an indoor cat, declawed, cannot survive outside. And, should you give her away, and she sprays at her new home, would they beat her? As for neutered males, "done" early, never knowing they need to spray---that also is not entirely true...that is an instinct. Sometimes, a male cat "just becomes a dominant male" and will spray "anything"--curtains, windows, chairs, walls, shoes, peoples legs---just seeing another cat out of a window...that happened to my Gucci. Unfortuantely, he also was escorted, in my arms, across the Bridge. I have a wonderful, experienced Vet...he made the suggestion after several visits with no medical problems and being "sprayed while we talked"; with an explanation...and we chose to "try" for years. I know we did what was right. Everyone has their own thoughts, and experiences...I've taken in a stray in the past 2 years, locked him in the spare bathroom, Jack used the bathtub at first---but he now is a great housecat...it "can" be done..it took more than a month. Choices---it's all about choices I guess