It depends. If it is a quilt that I need to get out the door fairly quickly, I use one of a couple of trusty patterns that I can whip up quickly.
If I am making something for me I like to try new patterns and fabrics.
But most of my quilts are gifts or donations so I tend to use the same patterns, a lot!!!! Because the fabric is usually so different for each one, it makes each quilt look and "feel" different. The pattern I use most calls for 12 to 18 fQ's and borders, you can change the look of a quilt really quickly by the fabrics you use.