I am left handed, but cut with right hand (with scissors). With my rotary cutter, I find I cut from the right side of the ruler more comfortably, having the bulk of fabric on my left, because I can see what I'm doing better. It gives me more confidence for a better cut. However, sometimes my ruler will get in my way because I usually use my 24" ruler for cutting & no real room to work here. If the whole ruler didn't come in so handy, I'd think about hacking it off to an 18" length.