i work in the finished basement in this house. it's been quite a change!
in the summer i need to have the dehumidifier running practically 24/7 and for winter i needed to add two wall-hung gas heaters.
i have a painted concrete floor with no water problems, but i do live in new jersey which is very humid. even with the humidity, no harm has come to my machines, if that's what you're worried about. and after a long time, fabric does get a musty smell, but it washes out.
from a mental health standpoint, it's nice and private and you can leave a mess if you want to, but it's away from the heart of the house and when you look out the windows all you see are feet.