Yes, you can do this. I originally bought a 9" Juki (very similar to the Janome) along with a Little Gracie II frame. Grace Frame Company offers a stitch regulator that can work with a whole bunch of small machines (read about it here:
http://www.graceframe.com/site/machi...itch-regulator) I will say that the stitch regulator worked very well.
Personally, I found stitching with a short-arm FAR too limiting. The throat space on the machine is really quite small, and if you're doing a large quilt, by the time you get to the end of the quilt, the amount of space you have to quilt in is very small. Some people can make it work and are happy with it, but I was not -- so I bought a 15" Bailey instead, and am much happier with that :)