I've used fleece on lots of small quilts (48" by 54" or smaller) both on my domestic machine and the Tin Lizzie 18. I drape the fleece right side up on my drafting/cutting table and let it relax overnight. Then I place the pieced top right side down on top and pin around the edges and place a few pins in the center. Stitch around the edges with 1/2" seam, leaving an opening for turning. Trim edges to 1/4", turn right side out. Then stitch 1/4" from edge to form a faux binding. Quilt using a fancy or straight stitch on the domestic machine (feed dogs up) or pin to leaders on the long arm and quilt with free form or panto. I think the trick is to let the fleece drape over the edges of the drafting/cutting table and relax, get the stretch out!