We have a new LQS that opened up here about two years ago. Within a year they had to move into a space twice as big as where they started out. Last year they won an award for "Best New Business" in town. I think that was a Chamber of Commerce award. Everytime I've been in there it's packed. The service is great and they have everything mentioned in the other "What do you like in a quilt shop" thread.
So..... it's possible!