Here I am, the bubble burster...
It's not crazy to want a better, more comfortable life. I moved to SC because I hate winter.
At 52, it is, unfortunately, not easy to find a new job. There is rampant age discrimination in the job market, but it's very difficult to prove it.
If you quit your job, you can't collect unemployment and SS is at least 10 years away. Can you retire now with a pension? That would help.
Two years worth of savings can disappear in what feels like a heartbeat. I don't know if you have health insurance through your job, but if you do, and you quit, what will you do? COBRA is expensive; have you taken that into account when you calculate that your savings will last 2 years?
Why don't you work toward your goal in stages? First, sell the house. If you make some $$ on the sale, you have more of a stash (had to get that quilting word in!) to plan with. Once it is sold you can decide whether to move to AZ or to just get yourself a little apartment nearer to your job and stay put for a while longer. A shorter commute might make a big difference in how you feel about your job - plus you have more time to yourself.
Bottom line - think long and hard before you pick up and move without a job.