the best reaction that I ever had was from my husbands grandmother, who at the time was in her mid 90's. She couldn't see too well anymore, and I wanted to do something special, so I made her a black and white log cabin. She looked at me and started to cry because someone thought of her and that I had made it just for her AND that she could see it. (well the pattern anyway)
I've had my fair share of people not appreciating things, and honestly, that's ok. They're not on my list anymore.