I most enjoy quilting for my local community. I don't as a rule donate to a big organization, as I prefer to get word of mouth of those who are needing a quilt. I also enjoy contributing to those on the board who have projects going that ask for help.
I just volunteered to make 5 infant quilts for a local volunteer group that mentors teen mothers. They are part of a community outreach program, not a national organization. This is the kind of thing I like to do.
As word gets around, more people tell me about those they know of who might be a candidate for a quilt and I do what I can.