Yes, but it has to be the coated aspirin, like Ecotrin. You can give your 110 lb GShepherd 1 tablet 3 times a day spread out if he/she is in a lot of discomfort, otherwise give your baby 1 tablet am and pm. We have 90 lb Airedale that we do this with. Helps with the pain of arthritis when he has a spell. We also give him Cosequin DS on a regular basis. You can get that at a reasonable price from Entirely Pets online. (No affiliation). Hope this helps. If you need to discuss this further, PM me.
uote=mimom]has anyone ever heard of giving a dog asprin, if so how many times a day can I give it to my 110lb german shepherd[/quote]