I've used hand and machine quilting on the same quilt. Unless you're planning for this to be show quilt that requires one or the other, but not both, don't sweat it. I started hand-quilting a baby quilt, then did the final border by machine so I could get it done and out the door. The mom loved that I was able to hand quilt part of it. The baby's 3 and they still love it :-).