With the pens, just soak the whole quilt in the washer on cold with no soap, gently agitate then spin it out. Then I was with a gentle detergent on warm an on the delicate cycle. Put in dryer and have never had any problems of any kind. I would be more worried about not being able to get a pencil out. No rubbing or erasing or anything with the pen. Just make sure to soak with only water before you use detergent. I don't have time to go back over every quilt marking to remove it.