I always remember the woman who set up a sewing room in the motorcycle storage area of a trailer. She rolled up the door and had the tiny space set up. Or the woman who sewed in the 5th wheel while traveling. My space is a tiny room that should have been a small bathroom. I am lucky it has a window.
It is doable. Invest in a sturdy portable sewing table. Limit your tools to the most valuable ones. I can get my tools into a roll around case setup and a bag for the mats and rulers. Have bag will travel is my motto. (I have four retreats in the next 3 months.)
One of the most creative quilters I ever met does her work in their rentals in Indiana and Florida. She explained just how she kept everything simple and it worked for her.