Sorry about your leg. I do hope you were climbing trees to bird watch when this happened!
You would end up with one big block. Sounds interesting. go as far as you can and if it gets to big to handle, Start another block. I really think one big LC would be difficult to manover after it gets to a certain size.
How big do you want it to be?
Maybe try 4 big blocks and sew them togeher for a larger quilt! Hope this helps your thought process!
peace :D