I believe at www.quiltingstencils.com there are pictures of the many ways the preprinted mini wholecloth have been finished. I saw one of the Pennsylvania Dutch queen preprinted wholecloth at a show in which of the motifs was quilted in a different color. I have quilted them with contrasting thread and varigated thread. Certainly the backing can be any color you want for a two sided quilt. I have a couple older wholecloth that are two sided with thread matching one side and contrast on the other.
I made one of the minis and double layered the top and cut out for a reverse applique frayed edge look. It was black on top with bright batik showing through.