I am in a quilt group that started about 30 years ago by way of a small quilt shop. The shop is long gone and only 2 are original members. As the years went by people dropped out and new people joined. Everyone brought a friend who brought a friend so we are all pretty good friends. We have a quilt guild in the area and I know some of the ladies but since I have my quilt friends I don't feel the need to join. I would give it a try maybe look for someone who maybe isn't already part of a clique and try and get to know her. I think it's a hit or miss with any guild. you won't know if you don't try.
Good luck.