As others said above, it depends on the needs. Our guild (Arkansas Quilters Guild) had someone from a local abuse shelter come to one of our meetings and asked for time to address our guild to state their needs. They didn't want money, they wanted quilts to give to those coming out of abusive home situations. They offer services to victims of domestic abuse, sexual violence, and child abuse. So we've been happily fulfilling their request. :) One way we do that is by offering "Take and Make" block kits, which are baggies that contain 2.5" strips for making simple 9-patch blocks. The quilters make the blocks and return them and we then package those with fabrics to make the complete quilt top. Quilters take a top kit and make it and return it and we then let that go out to whoever wants to quilt it. So no one person has to make the entire quilt, it really is a group effort. So far this year (we started this back in April) we've delivered about two dozen quilts to them and they are so appreciative. Below is a pic of the organization director with the quilts delivered last month.
Anyway, I would urge those interested to find out the needs of the organization and then work to help meet that need, whether it's with cash, time, or actual quilts.