Quilting comes and goes with me. I get burned out from designing and get busy with other things that keep me from quilting. Like "Do I search through fabrics online or do I spend my night with a video game?" I pick projects beyond what I think is my general skill level because I don't like the simple designs within my general skill level and then get frustrated with it.
But truly give up on it? Thought about it once. At the time I had only made three quilts and later had a huge falling out with each quilt recipiant (not all three at the same time). Honestly thought my quilting was cursed. But I talked about it on the board and people told me not to give up.