I use Marti Michelle's Machine Quilting By Sections method. I divide my pieced quilt into pieces, for the queen I'm working on I'm using 9 pieces about 36 inches square. I baste and quilt with a back that is stitch friendly (usually a print). After I've quilted all 9 fronts and backs, I join the fronts like usual with a 1/4 inch seam. Then I fold over an excess on the back (1 inch) into a half inch seam and sew it up the back. If I don't want the seam to show on front I hand stitch with a blind stitch or a whip stitch. If it doesn't show on the front I use the serpentine stitch on my machine (depends on how busy the front is.) This has taken away all the frustration in machine quilting for me.