I love the Bamboo batting from JoAnns. Everytime I get the chance to go there and I have a coupon, I use it on the bamboo batting. I read somewhere that you SHOULD use polyester in baby quilts as it is flame-retardant. I wasn't sure but checked the label on a bag of poly and it did say that. I have to admit I've never used cotton although I have some in my closet, once I got the bamboo I didn't care to use anything else.