I have found the new Clover Wonder clips to be helpful. I saw a review and bought some. I tried them on a project and they are great. I had tried the gluing method (using Steam a Seam) a quilt teacher showed us, as well as the binding clips.
Saying that, I still have several that need binding. I did machine bind a baby quilt and it worked wonderfully using the wonder clips. I think I will say that for me physically I prefer machine binding, but I do like how hand binding looks.