I have used upholstery sample fabric in a few quilts. They turned out great, in fact the ones I made for my mom and mom in law are the envy of all their friends. My advice would be to choose a simple pattern and sort the samples by weight and fiber content, try to keep it the same in each article. Also plan on using something light weight for the batting and back or it could be too heavy. They make nice warm comfy quilts.