What stage of the project are you at?
If it's quilted and bound, then let it be.
Figure out where the glitches are and "do better" next time.
If it's at a stage where it would be comparatively easy to fix it, then I would take it apart and redo it.
If the question is "how picky should YOU be?" - I can't answer that for you.
I know how picky I am - and wonky does bother me.