My mom lived in a two-bedroom house with my stepdad. When they moved into this house, my stepdad suggested that my mom use the large room for her sewing. They only slept in the bedroom at night, so using a smaller room didn't matter--plus it had a bathroom! think of the time she saved not having to leave the sewing room for that! 8^)
it was a great use of the space. and, to quote another wise woman, it's your house and you are the master!