Probably the biggest thing to conquer is the practice. It takes a while and then all of a sudden one day, you stitches are great! My most important things for successful FMQ:
Spray baste
Supreme Slider
Gloves (I prefer Machingers - they are cooler and better fitting than garden gloves - the best $9 I've spent)
Extra table on the left to hold the weight of the quilt
Music
Peace (family to leave me alone!)
So many people are just terrified to try it because they fear it won't be perfect. No one is perfect, not even the pros. Look closely at the magazines. Even on the covers sometimes it's not perfect. Keep your first practice sandwich and compare it later on. It's a hobby, it's supposed to be fun!