So many interesting replies to such a difficult question.
I've made a quilt for someone I thought wouldn't appreciate it, but I did it anyway. I knew I'd made a really good job of it, I knew how much time and love I put into it, but I mentally prepared myself to let go once it passed hands, knowing that it wouldn't be appreciated or looked after and wouldn't last long.
For me, once it left my hands I no longer had "ownership", and if they wanted to store it in the back of the cupboard and never use it, then that was their perogative and I wouldn't let it upset me.
To my utter surprise it was recieved with tears and much joy, and it has been absolutely treasured since the day I handed it over.
I think while some people have some terribly sad stories, it says more about the gift recipient, than the gift giver. And that we should keep making quilts because it makes US happy. If people don't appreciate them, it's their loss, not ours.
:-)