Well, no, not completely, not easily. If you want to just plop a 5" block next to a 7" block and next to that a 12" block, I haven't figured out how to do it. You can make a custom layout, but I find it very cumbersome to size and position the blocks in it. Or you can do a row quilt, where each row is made of a different size blocks, but I don't think you can put multiple size blocks in that row. I am hoping that someone with much more knowledge of EQ will tell me I'm wrong, and how it can be done.