I learned a lot from this thread. Did not know about Color Catchers, or Retayne or Synthrapol. I do pre-wash and have found a few fabrics that bleed. One I had to wash 3 times to feel comfortable with it. Actually, it was a small piece of fabric for a pillow case, and I just soaked it in the sink. Because I hand quilt, I would probably commit hari-kari (not sure if I spelled that right) if a worked on a quilt for a year and then the fabrics bled and ruined it.
Thanks everybody for all the great information.