I am on my very first quilt ever and I am doing it all by hand. I am just starting out in easy 4" squares. I do two of each for a total of 24 squares. Then I connect all of those squares. Now I am connecting the rows of 24 squares and doing 12 rows at a time. I am finding that a few of mine are not exact and I can pull just a little to get the seams to line up. One square I did need to cut down and re do it, plus I put one square on backwards! I am just going to keep going because some of them are not off by that far. I am trying to secure the corners as I go, so there is no spacing in each corner.
What kind of design are you doing?