The best suggestion I have seen is to look at the pictures on the shirts and cut them out in measurements where the finished size is divisible by 3. This way you can cut the smaller designs out without too much white space left over and cut out the bigger designs without anything cut off. Then fit them together like a puzzle. You can use the front and back of the t-shirts if there is a design on both. The t-shirt quilt book I got said that the t-shirt quilts are more challenging to quilt through and may be more appropriate to do on a LA. They are so much fun to do. I have made 2 already and have 3 more cut to start soon.