Poly can make some of the most durable quilts. Depending on the thickness of the fabric ... consider the thicker the fabric ( double knits) the larger the pieces should be. The heavy thick double knit type poly can be very difficult to work with in small pieces. Consider opening the seams if the fabric is bulky or intersecting seams will be very thick.
Do lower your iron temp... as poly melts at a cotton setting. Poly does not crease as well so some find it frustrating that they can not get that crisp seam press.