We had a slightly different situation. We have no kids and both hated our jobs. I was working to pay the mortgage on a big house in Mass. My mother died and left us a paid for condo 1/3 the size of our house in Ga. We had a huge several day yard sale to downsize, even had to give a bedroom set to charity because we couldn't sell it fast enough. We had friends in Ga so that wasn't a problem. We do miss some aspects of Mass. but don't miss the hated jobs. After 20 years, we've finally filled the condo with too much junk, but that's mostly because I'm too sick to swamp it out
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I agree with those who say to try to sell your house first. Then move to the area for a while on a rental basis to see if you still like it. Things do change over the years and you'll need to be sure you can get the medical care you need. It will be worth while storing your furniture for a while to see if your new area works, much cheaper then buying a mistake!! And May's tips are right on the money.
Good luck whatever you decide.