I have done a few queen quilts on my home machine and it was a bit of a challenge, but very doable. I wouldn't hesitate to do it again. But here are two sites to check out. The first is Diane Gaudynski's site. She is a master quilter who does all her award winning (and stunningly beautiful) work on her domestic machine. She gives lots of tips, hints and suggestions for getting great results. The second site is Leah Day's site. She mostly does smaller quilts, but she also has great ideas for quilting on a domestic machine.
http://dianegaudynski.blogspot.com/
http://www.freemotionquilting.blogspot.com/